Journal Club

This week, we spotlight a paper review by Oluwaseun Mogbojuri

Paper Title: Intermittent Preventive Treatment (IPT) and the spread of Drug Resistant Malaria.

Authored by: Miranda I. Teboh-Ewungkem, Angela Peace, Zhilan Feng, Olivia Prosper, Katharine Gurski, Carrie A. Manore

Intermittent Preventive Treatment (IPT) is a malaria preventive measure in which vulnerable asymptomatic individuals (especially children and pregnant women) are given a full curative dose of an antimalarial drug at specified intervals, regardless of whether they are infected with malaria or not.

In the study, the authors developed a compartmental mathematical model incorporating IPT and treatment of symptomatic humans which allowed them to analyze the contribution of each control strategy to the spread of parasite drug resistance.

They performed numerical simulations to examine the effect of treatment of symptomatic infections and IPT on the prevalence levels of both drug-sensitive and drug-resistant strains.

Their results show that the schedule of IPT may have a significant influence on the prevalence of resistant infections as well as the total infections of both strains.

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